GW-1516 (Cardarine) Side Effects
GW-1516 (Cardarine) is a PPARdelta agonist studied for endurance and metabolic effects. It was abandoned by its developer after showing dose-dependent cancer development in animal studies at doses and durations used in preclinical research. This is the most important safety consideration with this compound.
This page is for educational purposes only and is not medical advice. Side effects vary between individuals. All protocols at Peptides Thailand are individually prescribed by licensed physicians. Contact your doctor with any concerns during treatment.
GW-1516 was abandoned by GlaxoSmithKline and Ligand Pharmaceuticals after multi-organ carcinogenicity was observed in multi-year animal studies. This is not a marginal or contested finding. Informed consent and physician supervision are essential.
Side effects to be aware of
Carcinogenicity risk (animal studies)
Requires monitoringIn multi-year animal studies, GW-1516 caused dose-dependent tumour development across multiple organ types. Development was halted specifically because of this finding. The relevance to human therapeutic use is debated in the research community, but it remains the defining concern with this compound.
Short-term human tolerability
UncommonShort-term human trials that were completed before the programme was abandoned generally reported good short-term tolerability. Long-term human safety data does not exist because the programme was stopped.
Monitoring
The carcinogenicity finding from animal studies must be discussed with your physician before starting. Any use should be at the lowest possible dose for the shortest possible duration, with physician oversight and regular clinical review.
Who is a good candidate?
- Adults who have reviewed the animal carcinogenicity data with their physician and made an informed decision with full understanding of the risks
- Patients with any cancer history
- Those unwilling to accept uncertainty regarding long-term cancer risk
- Children and adolescents
Contraindications
Your physician screens for these conditions before prescribing. Do not attempt to self-prescribe.
- Any personal cancer history (significant precautionary contraindication)
- Pregnancy and breastfeeding
- Long-duration use protocols
When to contact your physician
- Nausea, vomiting, or digestive symptoms that are severe or do not ease within two weeks
- Any chest pain, palpitations, or significant change in heart rate
- Signs of allergic reaction: rash, hives, swelling of the face or throat, or difficulty breathing
- Injection site reactions that worsen, spread, or do not resolve within 72 hours
- Any new or worsening symptoms that concern you, regardless of whether they seem related to your protocol
- Changes in any monitored values outside the range your physician specified
If you are ever unsure, contact your physician. That is what they are there for.
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